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Description
Evidence in Opioid Use Disorder Several preclinical investigations focused on opioid-related behaviors
P =0.89) (Table 3)
By attaching to GLP-1 receptors on these structures, GLP-1RAs decrease dopamine release and therefore make addictive behaviors less rewarding
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Elevated dopamine feels good, but you can have too much of a good thing and become desensitized to it, gradually requiring higher doses, more frequently, to achieve the same effect
