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A heart rate that stays above 100 beats per minute at rest, palpitations that are accompanied by dizziness or pressure in the chest, or a sudden change in the pattern of symptoms are all reasons to seek prompt evaluation

Combining a hepatically-challenged metabolism of bupropion with the general metabolic demands of tirzepatide therapy requires careful monitoring of liver enzymes and possibly reduced dosing of bupropion

Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat

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A subsequent trial in obese patients with either non-insulin treated T2D or without T2D found an additional mean weight loss of 3.7 kg versus placebo [78]