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Description
Currently recommended pharmacotherapies in the practice guidelines from US, Europe, and Japan Evidence-based practice guidelines for the management of NASH/NAFLD were published by the American Association for the Study of Liver Disease (AASLD) in 2012 [5], the Japan Society of Gastroenterology (JSG)Japan Society of Hepatology (JSH) in 2014 [6], and the European Association for the Study of the Liver (EASD)European Association for the Study of Diabetes (EASL)European Association for the Study of Obesity (EASO) in 2016 [7]

Kidney Issues: These drugs can reduce blood flow to the kidneys, potentially causing kidney problems in people who already have kidney disease or other risk factors
Weight loss reduces cardiac workload and improves blood pressure and lipid profiles

Priorities for researchers include establishing standardized protocols to monitor metabolic markers, designing dosing strategies that minimize adverse effects, and defining clear metrics to evaluate their combined versus individual benefits
You try everything, lose a few pounds, and then watch it all come back
