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Description
The SURMOUNT-5 trial, published in 2025 in the New England Journal of Medicine, directly compared tirzepatide with semaglutide

Other side effects to be aware of include those in the eye (diabetic retinopathy) and serious allergic reactions

Most semaglutide programs in West Virginia start with a low dose that gradually increases to minimize nausea or digestive discomfort

Aim for 64-80 ounces of water daily

The FDA boxed warning specifically contraindicates certain GLP-1 receptor agonists in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)
