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Key Physiological Actions Affecting Energy: Enhanced insulin sensitivity and glucose utilization efficiency Reduced hepatic gluconeogenesis and glycogen breakdown Delayed gastric motility and prolonged nutrient absorption Central nervous system appetite regulation through hypothalamic pathways Modified incretin hormone signaling cascades These mechanisms collectively alter the bodys established energy homeostasis, requiring physiological adaptation periods that may manifest as temporary fatigue or altered energy perception patterns

These results indicate that expression screening is a useful system to identify GPCRs as targets of food components and strongly suggest that curcumin activates GPR55 as an agonist, which is involved in the physiological function of curcumin

Psychoneuroendocrinology 103 , 284295 (2019)

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