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In addition, functional ablation of TCF7L2 in proglucagon-expressing cells decreases proglucagon expression and GLP-1-positive cells in the gut, reducing plasma GLP-1 secretion [136]

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This genetic insight allows healthcare providers to personalize dose escalation timing and predict which patients might achieve goals at 7.5 milligrams versus those needing 15 milligrams

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Higher doses might be a little rougher in the first few weeks, especially if youre sensitive to nausea