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Enteroendocrine cells (EECs), specialized neuroendocrine cells of the intestinal epithelium, mediate this postprandial gut feedback, as they sense the luminal milieu and release gut peptides that influence metabolic homeostasis, such as GLP-1 and cholecystokinin (CCK) 16

This marked a significant advancement compared to older diabetes medications, some of which caused weight gain and occasional hypoglycemia (dangerously low blood sugar levels)

With continued treatment and gradual dose increases, many patients report minimal side effects by week 4 to 6

Ozempic has certain cardiovascular benefits while similar benefits for Zepbound havent been confirmed yet

Retatrutide is not yet FDA-approved at the time this guide was written