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Mice given extra GLP-1 (via gene therapy or a GLP-1 agonist drug) developed more oxidative, fatigue-resistant muscle fibers (more Type I fibers), built up greater muscle glycogen stores, and increased mitochondrial biogenesis changes that enhanced their endurance performance (1)

While this metabolic effect supports weight management, the primary driver of GLP-1mediated weight loss is reduced calorie intake rather than a substantial increase in energy expenditure