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The impact of GLP-1 RA on cardiovascular outcomes is unclear

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Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology

How GLP-1 Medications Quiet the Noise Mounjaro and Wegovy work primarily by mimicking GLP-1 and, in the case of tirzepatide, the GIP hormone as well gut hormones that regulate appetite, slow gastric emptying, and signal satiety to the brain

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