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Optometrists should perform a baseline dilated comprehensive eye examination on patients who take these medications for any reason to determine their pre-existing level of DR and whether they have any risk factors for developing NAION

"We think that some of these people may be changing behavior, nutrition, lifestyle, [and] also may be changing the hormones in their body by being on [GLP-1 medications], changing how their brain sort of operates or functions permanently," Narula said

Semaglutide exhibited the more potent weight-lowering effect compared to exenatide

GLP-1 RAs/metformin (WMD: 0.15

It has been shown that liraglutide promotes natriuresis by atrial natriuretic peptide (ANP) secretion from cardiomyocytes in an Epac2-depdenent manner ( Fibrosis GLP-1RAs have been shown to attenuate renal fibrosis