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Meta-analyses show mean differences in HbA1c reductions versus placebo of 1.4% to 0.5% [20, 22, 24,25,26,27]

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Despite these side effects, the majority of users tolerate the drug well, and serious complications are relatively rare3

Rats in the osteoporotic group showed a significant increase in the serum IL-6 by 1.92-fold compared to the control group

At present, no patent of crystallization and precipitation of semaglutide is found, the inventor researches a precipitation method in a semaglutide preparation process, and finds that diethyl ether is used as a solvent to have some problems, the diethyl ether precipitation has poor crystal form, only crude products can be obtained through centrifugation, impurities can be wrapped in the crude products in the centrifugation process to influence the purification and product quality in the later stage, according to the conventional methods in the field, diethyl ether is used as the solvent, when ether solvents such as diethyl ether and the like are selected, the crystallization is basically viscous, the crystal form is inhomogeneous, the filtration is slow, so the product can be obtained only by the centrifugation method generally, as the crystal form is inhomogeneous, the impurities are not easily filtered out by centrifugation, the impurities can be wrapped in the two products, and the example shows that after one-time purification, one main impurity is obviously larger, and a purer finished product can be obtained by more-time purification, the production efficiency, also affecting product quality