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Cortisol acts as a systemic effector of the HPA axis, whose secretion is closely connected with environmental and empirical events

Dose escalation schedule directly affects the timeline to therapeutic effect

For most people, these early side effects can be managed with dose adjustments, dietary changes, or supportive care

Microinjection of exendin-4 into the NTS reduces intake of palatable high-fat diet and inhibits food reward behavior [716], and hindbrain inhibition of GLP-1R via administration of exendin (939) into the 4th ventricle increases food intake [717]