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Similarly, in the United Kingdom Prospective Diabetes Study (UKPDS), only 34% of patients attained an A1c age 65) and patients with hepatic or renal disease are more likely to experience frequent and severe hypoglycemic reactions, particularly if the goals of therapy aim for inappropriately tight glycemic control (20)

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Following this strategy, different metabolic pathways for carbohydrate, lipid, and protein metabolism could be influenced simultaneously

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