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Background Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are a class of medications initially developed to treat type 2 diabetes (T2D) and obesity

GLP-1 receptor agonists (GLP-1RA) have received extensive attention due to their advantages such as strong hypoglycemic effect, low risk of hypoglycemia (single agent), good weight loss effect and cardiovascular benefits

Why weight comes back Weight regain is not a willpower failure

Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Weeks 13 and beyond: 8 to 12 mg once weekly (based on response and tolerance) This protocol reaches the therapeutic range in approximately 8 weeks

MarsoSPBainSCConsoliAEliaschewitzFGJdarELeiterLAet alSemaglutide and cardiovascular outcomes in patients with type 2 diabetes