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A meta-analysis of the effects of the current GLP-1RAs on body weight, glycemic control, and lipid profile revealed that tirzepatide, a dual GLP-1RA and GIP-RA, has the highest efficacy in improving glycemic control compared to other GLP-1RAs, suggesting a beneficial effect of targeting the GIP-R along with the GLP-1R

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In the first couple years, the participants did well in the program, but often relapsed once they left

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Furthermore, there is a correlation between improvements in sperm count and concentration and weight loss linked to GLP-1RA usage