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Some GLP-1 drugs appear more likely to cause gastrointestinal side effects than others

They are also seen as a key expansion direction for obesity and metabolic disease therapies

356: 2457 2471 [DOI] [PubMed] [Google Scholar] 7.Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, Baggio LL, Henkelman RM, Husain M, Drucker DJ

The commercial and clinical momentum is staggering

Short-acting agents, such as exenatide and lixisenatide, exert pronounced meal-time fullness primarily through delayed gastric emptying, while long-acting formulations including liraglutide, dulaglutide, and semaglutide sustain a more persistent satiety tone via direct activation of brain receptors