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Pharmacological investigations have revealed that dopamine agonists can alleviate RLS symptoms, whereas dopamine antagonists may exacerbate them [3]

However, although the preclinical studies cited above point toward potential metabolic effects of SDF-1, it is unknown whether there are any physiological or pharmacological consequences of DPP-4-mediated cleavage of SDF-1 for metabolic control in humans

The result is harder, drier stool that becomes difficult to pass

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For the first time, large numbers of patients are achieving sustained, clinically-significant weight loss, often 15 to 20 per cent of body weight in under a year