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2025;DOI:10.1001/jamasurg.2025.0001.

While SUSTAIN-6 and REWIND trials examined GLP-1 RA in diabetics with different cardiovascular risk profile, The Harmony Outcomes study enrolled patients with T2D and established atherosclerotic cardiovascular disease (ASCVD)

High-fat meals can delay absorption, potentially affecting how quickly the medication takes effect
Let the medication reach room temperature if it has been refrigerated
