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Endoscopic, surgical and other therapies A number of invasive therapies have been used in individuals with refractory diabetic gastroparesis, but none can currently be considered to have an established place in management

As many of their effects influence weight loss and management, the variety of formulations provide tailored treatment options for many individuals

Large cardiovascular outcome trials involving over 60,000 patients found no statistically significant increase in pancreatitis rates with GLP-1 agonists versus placebo

The guidance outlines five key recommendations relating to GLP-1RAs and GLP-1/GIPRAs and sedation or anaesthesia: All patients should be asked about the use of GLP-1RAs and GLP-1/GIPRAs before anaesthesia or sedation for surgical and endoscopic procedures and be involved in discussion and planning regarding the risk of aspiration

The only approved oral GLP-1 formulation Novo Nordisks Rybelsus (semaglutide) combines the same peptide as Novos injectable Ozempic and Wegovy formulations with an absorption enhancer (sodium N -(8-[2-hydroxybenzoyl] amino) caprylate, or SNAC)