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Am J Physiol Endocrinol Metabol
In terms of combination strategies, a series of open-label studies by Jensterle-Sever et al
Specifically, GLP1 is secreted by L cells and GIP by K cells in response to the presence of glucose in the gut lumen
Consistent with this, expression levels of the long noncoding RNA, maternally expressed 3 ( MEG3 ) and glucose transporter 2 ( SLC2A2 ), both of which contribute to insulin synthesis and secretion (4346), increased in a step-wise fashion from the -1 to -4 subclusters (Figure 3D)
That translates to roughly 50 pounds for someone starting at 220 pounds
