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Furthermore, inflammatory cells and cytokines (TNF, IL-1, IL-6, and monocyte chemoattractant protein-1 (MCP-1)) are thought to play important roles in the development and progression of atherosclerosis [37]
Improved glycemic control represents a primary mechanism
Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, and Seeley RJ
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T2DM is characterized by a chronic proinflammatory state marked by the overexpression of cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha, alongside chemokines and other proinflammatory mediators, which contribute to insulin resistance.108 Elevated concentrations of these inflammatory cytokines have been detected in the plasma and cerebrospinal fluid of patients with AD,109 and postmortem analyses revealed an inflammatory milieu within the AD brain,110 implicating inflammation as a contributory factor in the pathogenesis of dementia
