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Ripple effects already visible: GLP-1 uptake is slashing insulin pump adoption (~50%) and bariatric surgeries (2025%), while fueling a 33% CAGR boom in peptide manufacturing

Back Moore, B (1 Jan 1906) 'On the treatment of Diabetes mellitus by acid extract of Duodenal Mucous Membrane', Biochemical Journal , 1/1, 28-38

Commercializing CagriSema, if approved, could be challenging

00:13:50 Don Weinberger: So I remember in early twenty twenty four, uh FDA released a safety communication saying that they received several reports of suicidal ideation or action with GLP-1 agonists, but FDAs review of available evidence could not show a causal link, especially since the number of reports were really so limited

Results Trial participants ( n =66) were assessed for eligibility between 26 July 2022 and 31 January 2025 with eight failing screening, and 15 participants withdrew during the run-in period because they were unable to meet the demands of the trial protocol, particularly the requirement for frequent study visits and the volume and complexity of education and training delivered during the run-in phase