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Moderately severe or severely symptomatic hyponatremia: rapid increase in serum sodium with IV hypertonic saline followed by cause-specific treatment for hyponatremia Nonsevere symptoms (usually chronic hyponatremia): slow correction of serum sodium with cause-specific treatment for hyponatremia (e.g., fluid restriction in SIADH)

The titration period was followed by the use of a research-based AID system for 4 weeks

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[DOI] [PubMed] [Google Scholar] 653.De Jongh K.S., Murphy B.J., Colvin A.A., Hell J.W., Takahashi M., Catterall W.A

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