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Description
Cardiometabolic Monitoring : A mild, transient increase in resting heart rate (510 bpm) was observed, peaking around week 24 , likely due to glucagon receptor activation and elevated energy expenditure
All patients received medical, surgical, psychiatric, and nutritional evaluation and counseling
Nair KS
Randomization across the dose levels were 1:1:1 for PIONEER 1, 3, 8, and 9, whereas PIONEER 2 and 5 included only the 14 mg dose
Stopping GLP-1 treatment is not a failure
