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Nutrients, 17(1), 140

These agents work through local osmotic effects in the colon and are not systemically absorbed to any significant degree

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We identified P5 in a high-throughput autocrine-based screening of large combinatorial peptide libraries, and show that P5 promotes G-protein signalling comparable to GLP-1 and Exendin-4, but exhibited a significantly reduced -arrestin response

doi: 10.1186/s13075-018-1660-6
