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Brain-derived GLP-1 is synthesized in a subset of neurons in the NTS that project to GLP-1Rexpressing regions in the hindbrain and hypothalamus, including the paraventricular nucleus (PVN), dorsal medial nucleus of the hypothalamus, and arcuate nucleus (ARC), as well as the NTS itself

Consistent with our previous work (22), Dpp4 hep/ mice had significantly reduced Dpp4 mRNA expression in whole liver extracts (Supplemental Figure 2A)

The sense that tirzepatide is no longer working is almost always this metabolic adaptation rather than medication failure

It is used to treat T2DM and obesity, improve weight loss, and reduce the risk of significant heart disease such as heart attack or stroke in some adult patients