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Description
exenatide, lixisenatide) were designed to resist DPP-4 metabolism, and had half-lives of ~3hrs necessitating twice-daily or daily dosing
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Notably, immediate-release exenatide requires administration before meals, which affects both its efficacy and tolerability profile
In populations that largely did not suffer from HF at the time of the enrolment, treatment with empagliflozin, canagliflozin and dapagliflozin had been able to decrease the risk of new-onset HF events by about 30%
PMID: 40445127.
