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A completely different approach was employed by He et al

Perspectives in weight control in diabetesSGLT2 inhibitors and GLP-1-glucagon dual agonism

Bharucha AE, Charkoudian N, Andrews CN, et al

This review summarizes the current literature on the risks and benefits of GLP-1 receptor agonist use for both the mother and fetus, highlighting the need for ongoing high-quality research in this population

45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation
