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It is one of the most watched assets in the GLP-1 pipeline because it may push efficacy beyond current injectable therapies

According to FDA labeling, tirzepatide has not been studied in patients with a history of pancreatitis, and alternative therapies should be considered for these patients

These findings collectively emphasize that while GLP-1RAs are effective in reducing FBM, strategies to preserve or enhance SMM, such as resistance training and adequate protein intake, should be integral to obesity management

doi: 10.1056/NEJMoa2501006
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