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Many practitioners prefer gradual escalation in smaller increments than the 2.5 mg jumps used in clinical trials, particularly for researchers who experienced significant fatigue or body aches at prior dose increases

Tirzepatide treatment was not associated with excess cardiovascular risk (54, 74)

While these observational designs cannot prove causation, the consistency of findings across different databases, countries, and methodological approaches supports the reality of the effect

But, side effects often tend to be tolerable and fade over time

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