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Based on their response and comfort level, doses may be titrated slowly over several weeks

However, some scholars have proposed that the effect of GLP-1 in the liver is indirectly mediated by multiple mechanisms, such as reducing fat absorption or inhibiting fat cells through acyl-CoA synthetase long chain family member 1 (ACSL1), CCAAT/enhancer binding protein (C/EBP), peroxisome proliferator-activated receptor- (PPAR), and sterol regulatory element binding protein-1c (SREBP-1c) pathways to achieve the purpose of reducing liver lipids [38]

JMCP 27(3):354366 Trogdon JG, Finkelstein EA, Hylands T, Dellea PS, Kamal-Bahl SJ (2008) Indirect costs of obesity: a review of the current literature

"Efficacy and safety of anti-obesity drugs in metabolic dysfunction-associated steatotic liver disease: An updated review"