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Anecdotally, some users report that the appetite-suppressing effects weaken over time, necessitating dosage adjustments to sustain efficacy. The impact of GLP-1 use extends beyond just calorie-dense products, with most categories experiencing declines

Yet, we suggest that physicians should pay more attention to patients with diabetes who take GLP1-RAs for glucose control

For cardiovascular benefits, the timeline extends further

10,11 Regarding IOP-lowering mechanisms, GLP-1RAs have been shown to inhibit sodium-potassium ATPase in the choroid plexus, decreasing cerebrospinal fluid secretion and lowering intracranial pressure