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Obesity medicine physician Jessica Duncan discusses the article "GLP-1 weight regain: Why stopping medication leads to weight return." Jessica explains that expecting to maintain weight loss after abruptly stopping GLP-1 therapy is unrealistic because it ignores the physiological forces that defend a person's prior weight

Whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on extrahepatic tissues, or whether their action is direct, i.e., through activating GLP-1R on the hepatocytes, is still a controversial issue