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DeFronzo said a glucagon-like peptide 1 receptor agonist (GLP-1 RA) will correct six of the disturbances present in Type 2 diabetes individuals, sodium-glucose co-transporter 2 (SGLT2) inhibitor treatment corrects three of the metabolic abnormalities, and pioglitazone fixes four of the problems with some overlap with the GLP-1 RAs and SGLT2i

GLP-1 side effects GLP-1 medications have a different side effect profile, heavily weighted toward gastrointestinal symptoms: Nausea (the most common, affecting 40-50% initially, but typically improving over weeks) Bloating and abdominal discomfort The key difference is trajectory

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The Harmony Outcomes Trial, conducted in 2018, investigated the use of 3050 mg albiglutide once-weekly subcutaneous injection in 9463 patients with T2DM for a median of 1.5 years