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Through her leadership, the Obama administration seized on a moment when America started paying attention to food, and made fighting obesity a top priority both symbolically and legislatively

Insulin is co-crystalized with Zn 2+ in the secretory granules of the -cells [590,591] and Zn 2+ is co-secreted with insulin under conditions of hyperglycemia [592,593]

Since their first regulatory approval in 2005, glucagon-like peptide-1 (GLP-1) based therapies have played an important role in the treatment of patients with T2DM, improving glycemic control, reducing body weight, and reducing the risk of cardiovascular disease [20]

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By leveraging the high expression level of the Alb gene in hepatocytes, we targeted the Alb locus for the knock-in of the secretable Exe4