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However, the cardiovascular benefit of semaglutide was consistent across all body weight subgroups, showing no significant interaction between BMI or waist measurements and treatment effect. The SELECT trial showed that for every 5 kg lower baseline body weight, patients treated with semaglutide had a 4% lower risk of major cardiovascular events (hazard ratio 0.96)

Advances in drug discovery based on network pharmacology and omics technology

Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

Excess weight can lead to the accumulation of adiposity around the upper airway, which can obstruct proper breathing during sleep, resulting in OSA

Liraglutide for managing obesity in people aged 12 to 17 years (TA749)