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Glossary Abbreviations Used GLP-1 glucagon-like peptide-1 GPCR G-protein-coupled receptor GLP-1R glucagon-like peptide-1 receptor T1D type 1 diabetes T2D type 2 diabetes DPP-IV dipeptidyl peptidase IV NEP 24.11 neutral endopeptidase 24.11 Aib aminoisobutyric acid DOTA 1,4,7,10-tetraazacyclododecanetetraacetic acid AEEA aminoethylethanolamine GlcNAC N -acetylglucosamine LacNAC N -acetyllactosamine PEG polyethylene glycol DPC dodecylphosphocholine TFE 2,2,2-trifluoroethanol NTD N-terminal domain TM transmembrane ECL extracellular loop CD circular dichroism BIP biphenylalanine GR glucagon receptor GIP gastric inhibitory polypeptide LAR long-acting release PLGA poly(lactic- co -glycolic acid) POD protease-operated depot ABP arginine-grafted bioreducible polymer BCM -cell mass FPG fasting plasma glucose OGTT oral glucose tolerance test HbA1c glycated hemoglobin PET positron emission tomography MRI magnetic resonance imaging SPECT single-photon emission computed tomography VMAT2 vesicular monoamine transporter 2 SUR1 sulfonylurea receptor 1 GLUT2 glucose transporter 2 DTBZ dihydrotetrabenazine NOTA 1,4,7-triazacyclononanetriacetic acid DTPA diethylenetriaminepentaacetic acid DO3A 1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane STZ streptozocin Biographies Bikash Manandhar completed his Bachelor of Pharmacy (B.Pharm.) at the Kathmandu University, Nepal, in 2007