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Importantly, most subjects with exenatide-induced volume contraction were receiving drugs that inhibit the renin-angiotensin system and aldosterone formation

Perspective on the Rx Pipeline: Diabetes and GLP-1 Agonists Situation Summary Initial therapy for individuals with T2DM who are at high risk for CVD, heart failure (HF) and/or chronic kidney disease is metformin and a glucagon-like peptide 1 (GLP-1) or sodium glucose transporter ligand 2 (SGLT-2)

(Narrative review on GLP-1s, weight loss and fertility, including preconception safety considerations.) ScienceDirect+1 Sola-Leyva A, et al

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