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We identify only lst-1 and sygl-1, two of a number of previously reported targets, as likely the sole primary mRNA transcriptional targets of GLP-1 signaling that promote the germline stem cell fate

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G proteincoupled receptor that regulates glucose homeostasis by promoting cAMP production and insulin secretion in pancreatic -cells

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Similarly, studies have shown that GLP-1-based therapeutics can delay the progression of kidney disease in individuals with Type 2 diabetes, although the mechanisms are not well understood