glp-1 receptor agonist type 1 diabetes trial liraglutide agonists review and effects GLP-1: Genetic Variants Related to
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PLoS One 8 (4), e61965

J Mol Med (Berl) 2004;82(8):510529

This can happen without any external cause
Realworld studies demonstrate high discontinuation rates of GLP1RAs by up to 75% within the first year of use, predominantly driven by side effects 20-22

Another, larger meta-analysis reported no reduction in HF hospitalizations but did observe improvements in tissue Doppler measurements and diastolic function, suggesting possible benefits in diastolic HF [33]
