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For that reason, any use of microdosing requires structured evaluation and ongoing medical oversight
Initially developed for glycaemic control and more recently approved for obesity management, GLP1RAs exhibit CNS activity that intersects with neurobiological pathways involved in mood regulation, reward processing and cognitive function

PMID: 20923958

35 The Wnt/-catenin pathway, essential for bone formation, also affects adipose tissue fibrosis and energy metabolism, illustrating how bone-targeted interventions may lead to unexpected systemic consequences
