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Interestingly, W-24 (106), a non-peptide GLP-1RA, has been reported to inhibit inflammatory pain by stimulating the spinal cord GLP-1R for the release of analgesic -endorphin

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J Clin Endocrinol Metab (2021) 106(3):91221

Individual clones of HEK293 cells stably expressing select FRET reporters were obtained by G418 antibiotic resistance selection, as described previously 34