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Exposure was highly dependent on the calculated creatinine clearance

702 Therefore, parenteral administration is currently the most commonly used route of administration, with subcutaneous injection being the most widely used

The analysis of 4887 participants treated with tirzepatide and 2,328 participants in the control groups identified 142 participants who developed at least one MACE-4p (inclusive of cardiovascular mortality, myocardial infarction, stroke, and hospitalization for unstable angina) and confirmed the cardiovascular safety with an hazard ratio (HR) of 0.80 (95% CI 0.571.11) for the comparison between tirzepatide and controls

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Other microneedle shape variants, like bullet and conical shapes, were employed