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However, with proper nutrition, exercise, and monitoring, there was NO loss of bone after 1 year

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Therapy with GLP-1RA should therefore start with low doses that can be uptitrated ( GLP-1RA has been placed prominently in the international recommendations for the treatment of T2D as the first injectable agent before insulin due to the advantageous outcomes in cardiovascular safety studies that demonstrated a reduction of the combined cardiovascular endpoint three-component major adverse cardiovascular event (MACE-3

By early 2025: GLP-1 surpassed Ozempic in volume

Genetic and Metabolic Predictors of Treatment Response Some individuals exhibit greater weight loss and metabolic benefits with GLP-1 monotherapy, while others require dual or triple agonists to achieve similar effects
