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Effects of GLP-1 on the Energy Balance As previously introduced, GLP-1 is a peptide released in response to nutrient ingestion by the L-cells of the gastrointestinal tract, mainly located in the distal small intestine and colon [49,50], and by the nucleus of the solitary tract [51]

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Any extrapolation to non-HIV metabolic-syndrome cohorts therefore rests on small pilot work and mechanistic inference, not 2026 Phase 3 evidence

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