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Heart Failure: In patients with heart failure, stopping SGLT2 inhibitors may be associated with worsening of the condition

Liraglutide was shown to prevent synapse loss and deterioration of synapse plasticity in the hippocampus of APP/PS1 mice, while enhance synaptic plasticity in the control mice (158, 175)

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Cardiovascular and kidney outcomes and mortality with Long-Acting injectable and oral Glucagon-Like peptide 1 receptor agonists in individuals with type 2 diabetes: A systematic review and Meta-analysis of randomized trials

Seguidamente, se disearon estructuras unimoleculares de efecto multirreceptor como los coagonistas GIP/GLP-1, GLP-1/glucagn (GCG) y triagonistas GIP/GLP-1/GCG, generndose tambin formulaciones de administracin oral1,3,5