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Petrasca A, Hambly R, Kearney N, Smith CM, Pender EK, Mac Mahon J, et al
It not only increases the feeling of satiety and reduces appetite, leading to lower calorie intake, but it also affects the brains reward system, helping to curb cravings for high-calorie foods

Braun T, Voland P, Kunz L

Some berberine in particular do have modest weight-loss data behind them when taken orally at the right doses
That's where the Mayo Clinic Diet comes in
