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Comparisons were performed using one-way analysis of variance (ANOVA), and Spearmans correlations were calculated in GraphPad Prism 5 software (version 6.01)

Zepbound improves insulin sensitivity by approximately 30%, which contributes to more stable blood sugar levels and reduced cravings

Key features of retatrutide include: Acts as a triple agonist on GLP-1, GIP, and glucagon

Quianzon CCL, Shomal ME

Obesity Disease Burden and Population Health ROI Framework Economic Cost of Obesity, Comorbidity Cascade, and GLP-1 Pharmacotherapy Value-Based Evidence Reshape Global Treatment Investment The Global Obesity Forum estimated total annual economic costs of obesity at USD 4.32 trillion annually in 2025 , representing 2.92% of global GDP and exceeding the full economic output of Germany