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Chronic inflammation is sustained by a lack of Notch signaling leading to toll-like receptor stimulation with subsequent TNF- and IL-1 secretion causing dendritic cell activation and IL-23 release which polarizes Th17 cells and leads to increased IL-17

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The Medicines and Healthcare products Regulatory Agency (MHRA) approved Wegovy following clinical trials demonstrating significant weight reduction when combined with lifestyle interventions

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This article was written by Sara Katan, MSN, APRN-C Sara Katan is a certified Family Nurse Practitioner with over a decade of experience in nursing and advanced aesthetics