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Medications called GLP-1 receptor agonists act as a copy of this hormone

This delayed emptying contributes to increased satiety and reduced appetite, which supports weight loss but can also produce gastrointestinal side effects

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MOTS-C in particular degrades more rapidly than many other peptides once reconstituted

Thus, SUs that bind SUR1 to modulate K + ATP channels independently of glucose may also allow GLP-1R agonists to bypass their inherent glucose requirement by stimulating the downstream effects ordinarily associated with increased glucose